I would say yes to a point....
All engines are designed to operate within a certain temperature range. I think as long as you are within that range you will see maximized gas mileage. If you are running too hot, your cooling fans will be most likely be on and that will create more draw on your electrical system and the rule of thumb (don't quote me, but I've heard it pretty consistently) is for every 10amps you put on your electrical system, you lose .5 to 1 MPG.
If your engine is running too cold, your A/F ratio will probably run rich because your car will be trying to get itself up to normal operating temperature. I think of the two scenarios, getting too hot is more of a headache than getting too cold is.
My two cents...
Give a man a match, and he’ll be warm for a minute, but set him on fire, and he’ll be warm for the rest of his life.
2000 Pontiac Grand Prix GTP 3.8L SII S/C'd
15%-20% MPG increase at 1.5 Amps
2000 Jeep Grand Cherokee Limited 4.7L V8
No gains.